Bilateral tinnitus can be hereditary


Tinnitus on twins study
© Ingrid Balabanova

Christopher Cederroth presented at the TINNET mini conference meeting in Spain at the end of March. He spoke about his Bilateral tinnitus work that has just been published in the journal Genetics in Medicine.

The main finding from the recently published study is that researchers have been able to demonstrate the hereditary nature of certain forms of tinnitus. Bilateral tinnitus has been shown to depend on genetic factors, particularly in men. The twin study, which is published in the journal Genetics in Medicine, was conducted by researchers at Karolinska Institutet together with colleagues from the European research network TINNET.

Tinnitus, is experienced by 10 - 15 per cent of people in Sweden. For one or two per cent of the population, the symptoms are extremely distressing and impact adversely on daily activities, work and sleep. Tinnitus thus has negative social consequences for the sufferers, while being an important economic burden to society.

Tinnitus prevalence increases with age and is thought to be related to a number of environmental factors but little research has been done on the subject. There are also no effective cures for the condition, due possibly to the heterogeneity of the condition.

Unexpected results

Using data from the Swedish Twin Registry, researchers at Karolinska Institutet have found evidence that in some cases tinnitus has genetic causes.

“We’ve been able to show that different forms of tinnitus have a significant heritability and thus a dominant genetic influence over environmental factors,” says Christopher R. Cederroth at Karolinska Institutet’s Department of Physiology and Pharmacology.

When the researchers first examined all forms of tinnitus they made the same conclusions on heritability as others have reported. It was only after grouping the subjects by sex and unilateral/bilateral tinnitus that they uncovered the genetic correlation.

“This result is surprising and unexpected as it shows that, unlike the conventional view of tinnitus being driven by environmental factors, there is a genetic influence for bilateral tinnitus which is more pronounced in men” says Dr Cederroth.

Considerable clinical relevance

Their discovery also shows that bilateral and unilateral tinnitus constitutes two separate sub-groups, only one of which is influenced by genetic factors. This, claims Dr Cederroth, not only has considerable clinical relevance but is also important from a public health perspective:

“Tinnitus sufferers need better care and treatment than they’re currently getting. We need more genetic studies and a better molecular understanding of its generation, which could open unforeseen avenues to drug development.”

About the researcher

Christopher Cederroth is Assistant Professor at the Karolinska Institutet working on tinnitus: mechanisms, diagnostics and cure. Cederroth is co-leader of Working Group 4 (Genetics) in the TINNET European research network funded by the COST program under the Action number BM1306 working towards an Understanding of Tinnitus Heterogeneity

Victoria Adshead, editor in chief of Audio Infos United Kingdom