Regeneration of cells in the inner ear

Research

Researchers from the Stanford University Medical Center, California (USA) recently used single-cell gene expression profiles to create a gene expression map for the organ of Corti, in a mouse model.

The team used 2-day-old mice to obtain hair cells and supporting cells. The map they generated displays gene expression levels of 192 genes for all organ of Corti cell types ordered along the apex-to-base axis of the cochlea. These cells are known to play a decisive role in hearing, but little is known about the molecular biology that underlies how hair cells develop at specific locations.

Results of the study were published in the journal Cell Reports in June. The group identified patterns of gene expression that may determine whether inner pillar cells can give rise to new hair cells. They also found gradual changes in the expression of specific genes that may be important for establishing and maintaining a population of hair cells.

Single-cell gene expression analysis has developed rapidly in recent years. “Molecular gradients play a key role in developmental biology, but in the past researchers depended on identifying gradients in one molecule at a time,” explains Stefan Heller, PhD, professor of otolaryngology and senior author on the paper. “With these new techniques, we are identifying cells that, for example, have molecular characteristics of stem cells, by analyzing the expression of many genes all at once, and we know precisely where they are located.”

Source: MedicalXpress; Stanford University Medical Center; Waldhaus J, et al. Quantitative High-Resolution Cellular Map of the Organ of Corti. Cell Reports. 2015 Jun 9;11(9):1385-99.

C.S.

The future of hearing technology lies in GETTING CLOSER TO THE USER
The future of hearing technology lies in GETTING CLOSER TO THE USER

 

technology

MarioGuti - iStock

BIHIMA interviewed Sebastian Best, Head of Sound and Fitting in the Research and Development Department of Signia. Having worked for the company for almost 15 years, Sebastian has a wealth of experience in hearing technology development and discusses how processing strategies help people with hearing loss.

Stigma - a kleptes point in hearing improvement
Stigma - a kleptes point in hearing improvement

 

point-of-view

scaliger - iStock

In 502BC, a young lady named Alexandra walked in the foothills of Mount Olympus, holding a heavy vase strapped to her back and bearing the punitive marks pricked into her forehead for everyone to see.

WIDEX MOMENT App Named CES 2023 Innovation Awards Honouree
WIDEX MOMENT App Named CES 2023 Innovation Awards Honouree

 
 

awards

Widex

The WS Audiology brand Widex has announced that it has been named a CES 2023 Innovation Awards Honouree for its WIDEX MOMENT smartphone app.

Management psychology 4. The art of...TACTFUL CRITICISM
Management psychology 4. The art of...TACTFUL CRITICISM

 

management

Getty Images - whitemay

How do you criticise a colleague without hurting their feelings? How do you read their state of mind from their body language? Take some tips:

Jools marks the tempo on Specsavers hearing aids campaign
Jools marks the tempo on Specsavers hearing aids campaign

 

conferences

Specsavers

Musician and TV music show presenter Jools Holland just had his hearing tested. Despite exposure to loud sound throughout his career, his hearing checks out okay. But he'd hate to have hearing loss.

Audiology Conferences 2022: EUHA - Still the biggest audiology event in the world
Audiology Conferences 2022: EUHA - Still the biggest audiology event in the world

 
 

conferences

EUHA/Foto Rechtnitz EUHA President Beate Gromke (centre right) cuts the tape to symbolise the opening of the 2022 Congress.

One of the most welcome signs of the audiology sphere's recovery from the ravages of Covid-19 is the return of conferences, and this year's EUHA Congress in Hanover, Germany showed it is getting back to previous highs as the biggest hearing event of them all. Organisers registered an overall count of 7,400 visitors, which means the show's pre-pandemic target of 9,000 is again in sight.

 [ ... ]

Audiology conferences 2022: British Academy of Audiology
Audiology conferences 2022: British Academy of Audiology

 

conferences

BAA

The conference dynamic for 2022 was defined some time ago by the BAA. It was going to have a clinical focus. And it did... but no one forgot the other things that conference is about.

Company Directory

New products

DIY 3D-printing earmould production is a growing EU trend says Swiss software company behind Secret Ear BuilderDIY 3D-printing earmould production is a growing EU trend says Swiss software company behind Secret Ear Builder

 
 

3D-printing

© Cyfex

Switzerland-based CAD software producer Cyfex has highlighted a growing trend for hearing aid dispensers to set up their own earmould production lines using 3D-printing.

 [ ... ]

Slim and Xperienced - Signia launches Styletto AXSlim and Xperienced - Signia launches Styletto AX

 
 

new product

© Signia

Danish hearing aid brand Signia has launched an update of its sleek stigma-bust Styletto design, the Styletto AX, marking a further commitment by the manufacturer (WS Audiology) to personal wellness and fitness.

 [ ... ]

Lumity's arrival brings Phonak's Lumity's arrival brings Phonak's "best performance in speech understanding"

 

hearing aids

© Phonak

Phonak's first platform launch since its successful Paradise range is now upon us. It is called Lumity and it is being launched as the ultimate conversation aid.

 [ ... ]